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Nutritional CRO & Prüflabor

BioTeSys
Publikationen.

BioTeSys publiziert regelmäßig wissenschaftliche Artikel zu unterschiedlichen Themen aus dem Umfeld der Prüfung und wissenschaftlichen Absicherung von biologischen und chemischen Produkten.

Publikation: 06. September 2017

A.B.O.S. a novel data analysis tool evaluating complex data out of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

A.B.O.S. (A Better Omic System; version 1.1.0; Ars Nova AG, Esslingen, Germany) a simple, interactive software for the analysis of omics data has recently been developed to classify and evaluate biological properties or processes in complex datasets. The tool utilises self-learning algorithms that exploit group-specific properties from large datasets and applies a combination of multivariate analysis techniques such as principal component analysis (PCA), weighting the different variables/parameters according to their discriminatory power. Unlike PCA, however, the program can handle data that are not normally distributed and accounts for the presence of outliers and missing data. The software carries out predictive identifications based on pre-assigned learning groups that can be either detected automatically or defined manually. By combining all parameters shared by the members of each learning groups, the software calculates two ideal reference groups and classifies unknown elements based on their relative distance to these groups. Along with the proposed classification of samples, it also identifies the most important parameters that allow differentiating between classes.

Publikation: 01. Juli 2017

Aloysia citriodora extract targeting sports nutrition. In vitro study on anti-inflammatory effects by cyclooxygenases inhibition

Aloysia citriodora (L.) leaves are used as food and food supplements. A proprietary standardized Aloysia citriodora leaf extract was investigated for its anti-inflammatory effects by inhibition of cyclooxygenase (COX). Two isozymes were tested, ovine COX-1 isozyme and human recombinant COX-2 isozyme. Aloysia citriodora leaf extract showed significant dose-dependent effects to inhibit cyclooxygenases, demonstrating anti-inflammatory activity. Results may indicate beneficial effects for sports nutrition to prevent muscle soreness, muscle damage, and to improve recovery after physical exercise.

Publikation: 26. April 2017

The effectiveness of daily supplementation with 400 or 800 µg/day folate in reaching protective red blood folate concentrations in non-pregnant women: a randomized trial

Folate required to achieve desirable red blood cell (RBC) folate concentrations within 4-8 weeks pre-pregnancy is not known. We studied the effect of supplementation with 400 or 800 µg/day folate in achieving RBC-folate ≥906 nmol/L.

Publikation: 12. März 2017

Effects of a systemic enzyme therapy in healthy active adults after exhaustive eccentric exercise: a randomised, two-stage, double-blinded, placebo-controlled trial

Systemic enzyme therapy may improve symptoms of exhaustive eccentric exercise due to anti-inflammatory properties. In a randomised, placebo-controlled, two-stage clinical trial, systemic enzyme therapy (Wobenzym) was administered for 72 hours before and 72 hours following a day on which subjects performed an exhaustive eccentric exercise (isokinetic loading of the quadriceps). Efficacy criteria (maximal strength and pain) and time points were selected to account for the multidimensional nature of exercise-induced muscle damage symptoms. Subjects were randomised in a crossover (stage I, n=28) and parallel group design (stage II, n=44).

Publikation: 08. März 2017

Reduced muscular fatigue after a 12-week leucine-rich amino acid supplementation

Age-related muscle loss is characterised by a progressing decrease in muscle mass, strength and function. Besides resistance training and physical activity, appropriate nutrition that is rich in protein, especially branched-chain amino acids, is very important to support training effects and positively influence the protein synthesis to degradation ratio. The purpose of this study was to evaluate the effect of a 12-week leucine-rich amino acid supplementation in combination with moderate training.

Publikation: 10. Februar 2017

Effects of Mangifera indica (Careless) on Microcirculation and Glucose Metabolism in Healthy Volunteers

A commercial Mangifera indica fruit powder (Careless) showed beneficial acute effects on microcirculation in a randomized, double-blind, crossover pilot study. Here, long-term effects on microcirculation and glucose metabolism were investigated in a double-blind, randomized, placebo-controlled, 3-arm parallel-design study in healthy individuals.

Publikation: 02. Februar 2017

Effects of an L-arginine-based multi ingredient product on endothelial function in subjects with mild to moderate hypertension and hyperhomocysteinemia - a randomized, double-blind, placebo-controlled, cross-over trial

Nutrition plays an important role in prevention and management of cardiovascular diseases (CVD) in early stages. Recent research demonstrated beneficial effects of various nutritional ingredients on vascular health. The aim of the current study was to evaluate the effects of an L-arginine-based multi ingredient product (AbMIP) on vascular function.

Publikation: 04. Januar 2017

Effect of Two Different Multimicronutrient Supplements on Vitamin D Status in Women of Childbearing Age: A Randomized Trial

The German Nutrition Society raised in 2012 the recommended daily vitamin D intake from 200 to 800 international units (IU) to achieve 25-hydroxyvitamin D (25(OH)D) levels of at least 50 nmol/L, even when endogenous vitamin D synthesis is minimal such as in winter. We aimed to evaluate this recommendation in women of childbearing age.

Publikation: 30. September 2016

Plasma Carotenoids, Tocopherols, and Retinol in the Age-Stratified (35-74 Years) General Population: A Cross-Sectional Study in Six European Countries.

Blood micronutrient status may change with age. We analyzed plasma carotenoids, α-/γ-tocopherol, and retinol and their associations with age, demographic characteristics, and dietary habits (assessed by a short food frequency questionnaire) in a cross-sectional study of 2118 women and men (age-stratified from 35 to 74 years) of the general population from six European countries. Higher age was associated with lower lycopene and α-/β-carotene and higher β-cryptoxanthin, lutein, zeaxanthin, α-/γ-tocopherol, and retinol levels

Publikation: 29. August 2016

Analysis of the machinery and intermediates of the 5hmC-mediated DNA demethylation pathway in aging on samples from the MARK-AGE Study.

Gradual changes in the DNA methylation landscape occur throughout aging virtually in all human tissues. A widespread reduction of 5-methylcytosine (5mC), associated with highly reproducible site-specific hypermethylation, characterizes the genome in aging. Therefore, an equilibrium seems to exist between general and directional deregulating events concerning DNA methylation controllers, which may underpin the age-related epigenetic changes. In this context, 5mC-hydroxylases (TET enzymes) are new potential players.