BioTeSys publiziert regelmäßig wissenschaftliche Artikel zu unterschiedlichen Themen aus dem Umfeld der Prüfung und wissenschaftlichen Absicherung von biologischen und chemischen Produkten.
Publikation: 05. August 2016
Constipation is among the most common health impairments in Western countries. This study aimed to determine the effect of the chicory-derived fermentable dietary fiber Orafti® Inulin on stool frequency in healthy subjects with constipation. The study was conducted according to recent guidance documents for investigating bowel function and used a randomized, double-blind, placebo-controlled, cross-over design with a 2-week wash-out phase. Each study period comprised a run-in phase followed by 4 weeks daily intake of 3 × 4g inulin or maltodextrin (placebo). Forty-four healthy volunteers with constipation documented stool frequency and consistency, gastrointestinal characteristics and quality of life. Consumption of Orafti® Inulin significantly increased stool frequency compared to placebo (median 4.0 [IQR 2.5-4.5] versus 3.0 [IQR 2.5-4.0] stools/week, p = 0.038). This was accompanied by a softening of stools and trend toward higher satisfaction versus placebo (p = 0.059). In conclusion, Orafti® Inulin was effective in volunteers with chronic constipation and significantly improved bowel function.
Publikation: 11. Mai 2016
Aging is associated with alterations in the content and patterns of DNA methylation virtually throughout the entire human lifespan. Reasons for these variations are not well understood. However, several lines of evidence suggest that the epigenetic instability in aging may be traced back to the alteration of the expression of DNA methyltransferases. Here, the association of the expression of DNA methyltransferases DNMT1 and DNMT3B with age has been analysed in the context of the MARK-AGE study, a large-scale cross-sectional study of the European general population.
Publikation: 22. April 2016
The process of aging is determined by a complex interaction of endogenous factors such as genes combined with influencing exogenous factors such as nutrition and lifestyle. The progressive accumulation of damage caused by reactive species is often called oxidative stress and is associated with age-related diseases and aging. Defense mechanisms against oxidative stress involve the antioxidative network in which nutritional factors could intervene in a regulatory manner.
Publikation: 15. März 2016
Many people suffer from dry mouth (xerostomia) due to radiotherapy treatment of head and neck cancer, diseases like Sjogren’s syndrome or as adverse effects to prescribed medications. Salivary substitute products like gels or sprays are often used for treatment. Efficacy of those oral care products are regularly assessed by validated or even not validated questionnaires. To determine the adhesion effect over time more objectively a new and sensitive method was established. The following study was designed to assess the dwell time of different oral care products in vitro.
Publikation: 19. November 2015
Mangifera indica fruit preparation (Careless™) activates the evolutionary conserved metabolic sensors sirtuin 1 and adenosine monophosphate-activated protein kinase, which have been identified as playing a key role in microcirculation and endothelial function. Here, an acute effect of a single dose of 100 mg or 300 mg Careless™ on microcirculation was investigated in a randomized, double-blind, crossover pilot study in ten healthy women to determine the effective dosage.
Publikation: 09. Juli 2015
In two work packages of the MARK-AGE project, 37 immunological and physiological biomarkers were measured in 3637 serum, plasma or blood samples in five batches during a period of 4 years. The quality of the serum and plasma samples was very good as judged by the low number of biomarker measurements (only 0.2%) that were rejected because of a high hemolysis, icteria or lipemia of the samples. Using quality control samples, day-to-day and batch variations were determined. The mean inter-assay variation of the five batches were all below 8%, with an average inter-assay coefficient of variation of all biomarkers of 4.0%.
Publikation: 18. Juni 2015
Arthropathies present a major challenge for the public health system, both in terms of epidemiology and health economics, particularly against the background of demographic changes in the Western world. Much attention must be paid to prevention, because of the limited options and high technical and financial expenditure with respect to treatment. Among other factors, nutrition plays an important role.
Publikation: 01. Mai 2015
Mit der VO (EG) Nr. 1924/2006 über nährwert- und gesundheitsbezogene Angaben über Lebensmittel (sog. „Health Claims Verordnung“ – HCV) wird Lebensmittelunternehmen die Möglichkeit eröffnet, Lebensmittel mit einer wirkbezogenen Aussage zu vermarkten. Acht Jahre nach dem Inkrafttreten der Verordnung sollen in der gebotenen Kürze regulatorische Entwicklungen in der Umsetzung der HCV nachvollzogen und Informationen zur Vorgehensweise bei der Zulassung von Health Claims gegeben werden. Darüber hinaus wird auf die Anforderungen an eine wissenschaftliche Absicherung von gesundheitsbezogenen Angaben und die dafür notwendigen Evidenzkriterien eingegangen. Von der EFSA wurden hohe Hürden für die wissenschaftliche Absicherung aufgestellt. Mit dem Artikel sollen Schwächen bei der bisherigen Vorgehensweise dargestellt werden, ein Überblick über die noch offenen Themen gegeben und Möglichkeiten zur Bewältigung der wissenschaftlichen Anforderungen aufgezeigt werden.
Publikation: 02. April 2015
Many relevant EU projects were funded during last decade and MARK-AGE (European Study to Establish Biomarkers of Human Ageing) was the first focused on the identification of biomarkers connecting itself with a previous funded project, i.e. GEHA (Genetic of Healthy Ageing) that identified European families with longevity component (Franceschi et al., 2007). MARK-AGE was mainly a cross sectional study, based on definite assumptions and focused on an age range between 34 and 75 years, in order to identify early biomarkers of biological vs. chronological age, potentially capable of predicting the rate of ageing later in life.
Publikation: 26. März 2015
Within the MARK-AGE project, a population study (3337 subjects) was conducted to identify a set of biomarkers of ageing which, as a combination of parameters with appropriate weighting, would measure biological age better than any single marker. The MARK-AGE project involves 14 European countries and a total of 26 research centres